T-cryptantigen (TCA) activation in sever pneumonia complicated with multiple organ failure

Qiushi Wang; Delong Liu; Yingzhe Bai

doi:10.1016/j.transci.2010.10.008

T-cryptantigen (TCA) activation in sever pneumonia complicated with multiple organ failure

Transfus Apher Sci. 2010 Dec;43(3):361-364. doi: 10.1016/j.transci.2010.10.008. Epub 2010 Nov 13.

Authors

Qiushi Wang¹, Delong Liu², Yingzhe Bai²

Affiliations

¹ Department of Blood Transfusion, Shengjing Hospital, China Medical University, Shenyang 110004, China. Electronic address: Wangqs18@126.com.
² Department of Blood Transfusion, Shengjing Hospital, China Medical University, Shenyang 110004, China.

PMID: 21075688
DOI: 10.1016/j.transci.2010.10.008

Abstract

A 19-month-old boy presented RBC T-cryptantigen (TCA) activation with severe pneumonia complicated with abnormal coagulation. The boy received fresh frozen plasma before TCA activation was confirmed. He developed hemolysis and multiple organ failure. The hemolysis anemia was successfully treated with washed RBC transfusion. However, he had to use dialysis because of renal dysfunction. The case prompted an urgent call to screen RBC TCA-activation in selective pediatric patients.

Publication types

Case Reports

MeSH terms

Anemia / etiology
Antigens, Tumor-Associated, Carbohydrate / metabolism*
Erythrocyte Transfusion
Erythrocytes
Hemolysis
Humans
Infant
Male
Multiple Organ Failure / etiology*
Multiple Organ Failure / therapy
Plasma Exchange
Pneumonia / complications*
Pneumonia / therapy
Renal Dialysis

Substances

Antigens, Tumor-Associated, Carbohydrate
Thomsen-Friedenreich antigen