Disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules via covalent layer-by-layer assembly

Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):385-90. doi: 10.1016/j.colsurfb.2010.09.024. Epub 2010 Nov 11.

Abstract

The disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules have been fabricated via the covalent layer-by-layer assembly between the amino groups of chitosan (CS) and the aldehyde groups of the oxidized sodium alginate (OSA) onto the sacrificial templates (polystyrene sulfonate, PSS) which was removed by dialysis subsequently. The covalent crosslinking bonds of the multilayer microcapsules were confirmed by FTIR analysis. The TEM analysis showed that the diameter of the multilayer microcapsules was <200nm. The diameter of the multilayer microcapsules decreased with the increasing of the pH values or the ionic strength. The pH and ionic strength dual-responsive multilayer microcapsules were stable in acidic and neutral media while they could disintegrate only at strong basic media.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsules
  • Digestive System / pathology
  • Drug Carriers
  • Electrolytes*
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Ions
  • Materials Testing
  • Microscopy, Electron, Transmission / methods
  • Microspheres
  • Polystyrenes / chemistry
  • Spectroscopy, Fourier Transform Infrared / methods
  • Time Factors

Substances

  • Capsules
  • Drug Carriers
  • Electrolytes
  • Ions
  • Polystyrenes
  • polystyrene sulfonic acid