Abstract
Two cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives were synthesized as antioxidants against light-induced retinal degeneration. Whereas nitrone 10 significantly protected retina against bright fluorescent light exposure when injected into the vitreous at 1 mM, no protection was observed with nitrone 6. The parent compound α-phenyl-N-tert-butyl nitrone also exhibited protective activity at 9 mM but not at 1 mM. This suggests that nitrone 10 may be a candidate for the treatment of retinal diseases.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / chemistry*
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Antioxidants / therapeutic use
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Cholesterol / analogs & derivatives*
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Cholesterol / chemical synthesis
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Cholesterol / chemistry*
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Cholesterol / therapeutic use
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Cyclic N-Oxides / chemical synthesis
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Cyclic N-Oxides / chemistry*
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Cyclic N-Oxides / therapeutic use
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Disaccharides / chemical synthesis
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Disaccharides / chemistry*
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Disaccharides / therapeutic use
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Imines / chemical synthesis
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Imines / chemistry*
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Imines / therapeutic use
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Light*
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Rats
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Reactive Oxygen Species / metabolism
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Retinal Degeneration / prevention & control*
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Retinal Diseases / drug therapy
Substances
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Antioxidants
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Cyclic N-Oxides
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Disaccharides
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Imines
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Reactive Oxygen Species
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phenyl-N-tert-butylnitrone
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Cholesterol