Integration of image exposure time into a modified laser speckle imaging method

Phys Med Biol. 2010 Nov 21;55(22):6857-66. doi: 10.1088/0031-9155/55/22/016. Epub 2010 Nov 3.

Abstract

Speckle-based methods have been developed to characterize tissue blood flow and perfusion. One such method, called modified laser speckle imaging (mLSI), enables computation of blood flow maps with relatively high spatial resolution. Although it is known that the sensitivity and noise in LSI measurements depend on image exposure time, a fundamental disadvantage of mLSI is that it does not take into account this parameter. In this work, we integrate the exposure time into the mLSI method and provide experimental support of our approach with measurements from an in vitro flow phantom.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Lasers*
  • Molecular Imaging / methods*
  • Phantoms, Imaging
  • Time Factors