Positive reinforcement for viruses

Frederic Vigant; Michael Jung; Benhur Lee

doi:10.1016/j.chembiol.2010.10.002

Positive reinforcement for viruses

Chem Biol. 2010 Oct 29;17(10):1049-51. doi: 10.1016/j.chembiol.2010.10.002.

Authors

Frederic Vigant¹, Michael Jung, Benhur Lee

Affiliation

¹ Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Virus-cell membrane fusion requires a critical transition from positive to negative membrane curvature. St. Vincent et al. (2010), in PNAS, designed a class of antivirals that targets this transition. These rigid amphipathic fusion inhibitors are active against an array of enveloped viruses.

Abstract

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