Abstract
Objective:
To assess the epidemiologic characteristics of invasive pneumococcal diseases (IPD) among a population in a pediatric hospital in Mexico City and analyze mortality-related risk factors, serotype distribution and antibiotic susceptibility related to S.pneumoniae.
Material and methods:
We performed a retrospective review of IPD cases at a third level pediatric hospital between 1997-2004.
Results:
A total of 156 patients were included. The mortality rate was 27.5% and was associated with six pneumococcal serotypes: 14, 6B, 23F, 6A, 19F and 19A. There was no relationship between mortality and antimicrobial susceptibility pattern. A total of 28.2% of isolates were resistant to penicillin and 24.6% were resistant to cefotaxime. A statistically significant relationship was observed between mortality and previous underlying disease (CI 95%; 2.5-18.3; p< 0.05) using a multivariate logistic regression model.
Conclusions:
Our outcomes show that IPD mortality in our population is closely related to underlying disease and to six serotypes, five of which are included in the 7-valent pneumococcal conjugate vaccine.
MeSH terms
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Child
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Child Day Care Centers
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Child, Preschool
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / epidemiology
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Community-Acquired Infections / microbiology
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Community-Acquired Infections / mortality
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Cross Infection / drug therapy
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Cross Infection / epidemiology
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Cross Infection / microbiology
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Cross Infection / mortality
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Disease Susceptibility
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Drug Resistance, Microbial
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Female
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Heptavalent Pneumococcal Conjugate Vaccine
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Hospital Mortality*
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Hospitals, Pediatric / statistics & numerical data*
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Hospitals, Urban / statistics & numerical data*
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Host-Pathogen Interactions
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Humans
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Infant
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Infant, Newborn
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Male
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Mexico
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Pneumococcal Infections / drug therapy
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Pneumococcal Infections / epidemiology*
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Pneumococcal Infections / microbiology
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Pneumococcal Infections / mortality
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Pneumococcal Infections / prevention & control
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Pneumococcal Vaccines
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Retrospective Studies
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Risk
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Serotyping
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Sex Distribution
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / isolation & purification
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Young Adult
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beta-Lactams / pharmacology
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beta-Lactams / therapeutic use
Substances
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Heptavalent Pneumococcal Conjugate Vaccine
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Pneumococcal Vaccines
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beta-Lactams