One-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids

Malose Jack Mphahlele; Mamasegare Mabel Mphahlele

doi:10.3390/molecules15107423

One-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids

Molecules. 2010 Oct 22;15(10):7423-37. doi: 10.3390/molecules15107423.

Authors

Malose Jack Mphahlele¹, Mamasegare Mabel Mphahlele

Affiliation

¹ Department of Chemistry, University of South Africa, Pretoria, South Africa. mphahmj@unisa.ac.za

Abstract

Palladium-catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boronic Acids / chemistry*
Catalysis
Crystallography, X-Ray
Cyclooxygenase Inhibitors / chemical synthesis
Palladium / chemistry
Quinolines / chemical synthesis*
X-Rays

Substances

Boronic Acids
Cyclooxygenase Inhibitors
Quinolines
Palladium