Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2

Kazuko Yoshikawa; Chiho Yagi; Hiroshi Hama; Masami Tanaka; Shigenobu Arihara; Toshihiro Hashimoto

doi:10.1021/np100283t

Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2

J Nat Prod. 2010 Nov 29;73(11):1763-6. doi: 10.1021/np100283t. Epub 2010 Oct 20.

Authors

Kazuko Yoshikawa¹, Chiho Yagi, Hiroshi Hama, Masami Tanaka, Shigenobu Arihara, Toshihiro Hashimoto

Affiliation

¹ Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima 770-8514, Japan. yosikawa@ph.bunri-u.ac.jp

PMID: 20961090
DOI: 10.1021/np100283t

Abstract

Four new resin glycosides, namely, ipomotaosides A-D (1-4), were isolated from the dried aerial parts of Ipomoea batatas. The structures of 1-4 were elucidated by analysis of their spectroscopic data and by chemical derivatization and were tested for their anti-inflammatory activity against cyclooxygenase (COX)-1 and -2.

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cyclooxygenase 1 / drug effects
Cyclooxygenase 2 / drug effects
Cyclooxygenase Inhibitors / chemistry
Cyclooxygenase Inhibitors / isolation & purification*
Cyclooxygenase Inhibitors / pharmacology*
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology*
Ipomoea batatas / chemistry*
Japan
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Resins, Plant / chemistry

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Glycosides
Resins, Plant
Cyclooxygenase 1
Cyclooxygenase 2