IView: introgression library visualization and query tool

BMC Bioinformatics. 2010 Oct 7;11 Suppl 6(Suppl 6):S28. doi: 10.1186/1471-2105-11-S6-S28.

Abstract

Background: An introgression library is a family of near-isogenic lines in a common genetic background, each of which carries one or more genomic regions contributed by a donor genome. Near-isogenic lines are powerful genetic resources for the analysis of phenotypic variation and are important for map-base cloning genes underlying mutations and traits. With many thousands of distinct genotypes, querying introgression libraries for lines of interest is an issue.

Results: We have created IView, a tool to graphically display and query near-isogenic line libraries for specific introgressions. This tool incorporates a web interface for displaying the location and extent of introgressions. Each genetic marker is associated with a position on a reference map. Users can search for introgressions using marker names, or chromosome number and map positions. This search results in a display of lines carrying an introgression at the specified position. Upon selecting one of the lines, color-coded introgressions on all chromosomes of the line are displayed graphically.The source code for IView can be downloaded from http://xrl.us/iview.

Conclusions: IView will be useful for those wanting to make introgression data from their stock of germplasm searchable.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Genetic Markers / genetics
  • Genomic Library*
  • Genomics / methods*
  • Genotype
  • Phenotype
  • Quantitative Trait Loci
  • Software*
  • User-Computer Interface

Substances

  • Genetic Markers