Abstract
Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation. Our studies provide further evidence for broad conservation of insulin/insulin-like growth factor (IGF) functions in developmental speed control.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Animals
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Caenorhabditis elegans / cytology*
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Caenorhabditis elegans / drug effects
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Caenorhabditis elegans / growth & development*
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism*
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Dimethylphenylpiperazinium Iodide / pharmacology
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Forkhead Transcription Factors
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Insulin / metabolism*
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Larva / drug effects
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Larva / growth & development
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Larva / metabolism
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Receptor, Insulin / genetics
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Receptor, Insulin / metabolism
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Signal Transduction* / drug effects
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Somatomedins / metabolism*
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Time Factors
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Transcription Factors / metabolism
Substances
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Caenorhabditis elegans Proteins
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Forkhead Transcription Factors
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Insulin
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Somatomedins
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Transcription Factors
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daf-16 protein, C elegans
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Dimethylphenylpiperazinium Iodide
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DAF-2 protein, C elegans
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Receptor, Insulin