Abstract
SIRT1 is an NAD+-dependent deacetylase in mammalian cells and plays important roles in senescence, cell death and tumorigenesis. To clarify the regulation of SIRT1 expression and activity is crucial for scientists to understand the biological function of SIRT1. This review mainly focuses on the mechanisms by which SIRT1 expression and activity are regulated.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Forkhead Box Protein O3
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Forkhead Transcription Factors / physiology
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Gene Expression Regulation, Enzymologic
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Humans
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Kruppel-Like Transcription Factors / physiology
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Sirtuin 1 / genetics*
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Sirtuin 1 / metabolism
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Tumor Suppressor Protein p53 / physiology
Substances
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Forkhead Box Protein O3
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Forkhead Transcription Factors
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Kruppel-Like Transcription Factors
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Tumor Suppressor Protein p53
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SIRT1 protein, human
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Sirtuin 1