Pregnancy: tolerance and suppression of immune responses

Anne Leber; Maria Laura Zenclussen; Ana Teles; Nadja Brachwitz; Pablo Casalis; Tarek El-Mousleh; Federico Jensen; Katja Woidacki; Ana Claudia Zenclussen

doi:10.1007/978-1-60761-869-0_25

Pregnancy: tolerance and suppression of immune responses

Methods Mol Biol. 2011:677:397-417. doi: 10.1007/978-1-60761-869-0_25.

Authors

Anne Leber¹, Maria Laura Zenclussen, Ana Teles, Nadja Brachwitz, Pablo Casalis, Tarek El-Mousleh, Federico Jensen, Katja Woidacki, Ana Claudia Zenclussen

Affiliation

¹ Department for Neurosurgery, Charite, Medical University of Berlin, Berlin, Germany.

PMID: 20941623
DOI: 10.1007/978-1-60761-869-0_25

Abstract

Presence of foreign tissue in a host's body would immediately lead to a strong immune response directed to destroy the alloantigens present in fetus and placenta. However, during pregnancy, the semiallogeneic fetus is allowed to grow within the maternal uterus due to multiple mechanisms of immune tolerance, which are discussed in this chapter.

MeSH terms

Cells, Cultured / immunology
Dendritic Cells / immunology
Female
Fetus / immunology
Heme Oxygenase-1 / immunology*
Histocompatibility Antigens Class I / immunology
Humans
Immune Tolerance / immunology*
Isoantigens / immunology*
Killer Cells, Natural / immunology
Mast Cells / immunology
Placenta / immunology*
Pregnancy
T-Lymphocytes, Regulatory / immunology*
Uterus / immunology

Substances

Histocompatibility Antigens Class I
Isoantigens
Heme Oxygenase-1