Abstract
Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Plant Roots / chemistry
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Platycodon / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Saponins
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Triterpenes
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deapio-platycodin D2
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deapio-platyconic acid B lactone
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platyconic acid B lactone