Abstract
A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Cohort Studies
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Enzyme-Linked Immunosorbent Assay
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Europe / epidemiology
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Female
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Gene Products, gag / genetics
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Gene Products, gag / immunology
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Genes, Viral / genetics
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HIV Infections / blood
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HIV Infections / virology*
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HIV-1*
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Hepatitis C, Chronic / blood
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Hepatitis C, Chronic / virology*
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Humans
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Interferon-gamma / blood
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Leukemia Virus, Murine / genetics
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Leukemia Virus, Murine / isolation & purification*
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Leukocytes, Mononuclear / virology
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Male
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Middle Aged
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Polymerase Chain Reaction
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Retroviridae Infections / blood
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Retroviridae Infections / epidemiology*
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Retroviridae Infections / virology
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Risk Factors
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Tumor Virus Infections / blood
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Tumor Virus Infections / epidemiology*
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Tumor Virus Infections / virology
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United Kingdom / epidemiology
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Viral Envelope Proteins / genetics
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Young Adult
Substances
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Gene Products, gag
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Viral Envelope Proteins
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Interferon-gamma