The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men

Barış Saylam; Ozan Efesoy; Selahittin Cayan

doi:10.1016/j.fertnstert.2010.09.021

The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men

Fertil Steril. 2011 Feb;95(2):809-11. doi: 10.1016/j.fertnstert.2010.09.021. Epub 2010 Oct 8.

Authors

Barış Saylam¹, Ozan Efesoy, Selahittin Cayan

Affiliation

¹ Department of Urology, University of Mersin School of Medicine, Mersin, Turkey.

PMID: 20934689
DOI: 10.1016/j.fertnstert.2010.09.021

Abstract

We investigated the effect of letrozole, an aromatase inhibitor, on body mass index, serum hormones, and sperm parameters in infertile men with decreased T:E(2) ratios. All sperm parameters increased after letrozole treatment. Letrozole may be effectively used to improve sperm parameters in infertile men with a low serum T:E(2) ratio.

Publication types

Clinical Trial

MeSH terms

Adult
Aromatase Inhibitors / pharmacology
Body Mass Index*
Estradiol / blood
Hormones / blood*
Humans
Infertility, Male / blood*
Infertility, Male / pathology*
Infertility, Male / physiopathology
Letrozole
Male
Middle Aged
Nitriles / pharmacology*
Semen Analysis
Spermatozoa / drug effects*
Spermatozoa / pathology
Testosterone / blood
Triazoles / pharmacology*

Substances

Aromatase Inhibitors
Hormones
Nitriles
Triazoles
Testosterone
Estradiol
Letrozole