A new monoterpenoid glycoside from Myrica esculenta and the inhibition of angiotensin I-converting enzyme

Chem Pharm Bull (Tokyo). 2010 Oct;58(10):1408-10. doi: 10.1248/cpb.58.1408.

Abstract

One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 µM, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07-1.41% at concentration of 100 µM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / chemistry*
  • Angiotensin-Converting Enzyme Inhibitors / isolation & purification
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Myrica / chemistry*
  • Peptidyl-Dipeptidase A / chemistry*
  • Peptidyl-Dipeptidase A / metabolism
  • Plant Leaves / chemistry

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Glycosides
  • Monoterpenes
  • myresculoside
  • Peptidyl-Dipeptidase A