Convergent synthesis of geometrically disassembling dendrimers using Cu(I)-catalyzed C-O bond formation

Org Lett. 2010 Nov 5;12(21):4944-7. doi: 10.1021/ol102081q.

Abstract

The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carbon / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Dendrimers / chemical synthesis*
  • Iodides / chemistry*
  • Molecular Structure
  • Oxygen / chemistry*

Substances

  • Dendrimers
  • Iodides
  • Carbon
  • Copper
  • cuprous iodide
  • Oxygen