Carbazoles and coumarins from Clausena harmandiana stimulate glucose uptake in L6 myotubes

Diabetes Res Clin Pract. 2010 Dec;90(3):e67-71. doi: 10.1016/j.diabres.2010.09.005.

Abstract

Two carbazoles (compounds 1 and 2) and one coumarin (compound 8) from Clausena harmandiana exhibited significant glucose uptake activity in L6 myotubes in a time and dose dependent manner. In addition, compounds 2 and 8 were inhibited by p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinases, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbazoles / pharmacology*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Clausena / chemistry
  • Coumarins / pharmacology*
  • Cycloheximide / pharmacology
  • Cytochalasin B / pharmacology
  • Deoxyglucose / metabolism
  • Humans
  • Imidazoles / pharmacology
  • Muscle Fibers, Skeletal / drug effects
  • Muscle Fibers, Skeletal / metabolism*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Pyridines / pharmacology
  • p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors

Substances

  • Carbazoles
  • Coumarins
  • Imidazoles
  • Plant Extracts
  • Pyridines
  • Cytochalasin B
  • Cycloheximide
  • Deoxyglucose
  • p38 Mitogen-Activated Protein Kinases
  • SB 203580