Abstract
Two carbazoles (compounds 1 and 2) and one coumarin (compound 8) from Clausena harmandiana exhibited significant glucose uptake activity in L6 myotubes in a time and dose dependent manner. In addition, compounds 2 and 8 were inhibited by p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinases, respectively.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Carbazoles / pharmacology*
-
Cell Survival / drug effects
-
Cells, Cultured
-
Clausena / chemistry
-
Coumarins / pharmacology*
-
Cycloheximide / pharmacology
-
Cytochalasin B / pharmacology
-
Deoxyglucose / metabolism
-
Humans
-
Imidazoles / pharmacology
-
Muscle Fibers, Skeletal / drug effects
-
Muscle Fibers, Skeletal / metabolism*
-
Plant Extracts / pharmacology
-
Plant Roots / chemistry
-
Pyridines / pharmacology
-
p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
Substances
-
Carbazoles
-
Coumarins
-
Imidazoles
-
Plant Extracts
-
Pyridines
-
Cytochalasin B
-
Cycloheximide
-
Deoxyglucose
-
p38 Mitogen-Activated Protein Kinases
-
SB 203580