Trypanocidal activity of lipophilic diamines and amino alcohols

C O R Júnior; R O Alves; C A M Rezende; C F da Costa; H Silva; M Le Hyaric; A P S Fontes; R J Alves; A J Romanha; M V de Almeida

doi:10.1016/j.biopha.2010.06.002

Trypanocidal activity of lipophilic diamines and amino alcohols

Biomed Pharmacother. 2010 Nov;64(9):624-6. doi: 10.1016/j.biopha.2010.06.002. Epub 2010 Jul 21.

Authors

C O R Júnior¹, R O Alves, C A M Rezende, C F da Costa, H Silva, M Le Hyaric, A P S Fontes, R J Alves, A J Romanha, M V de Almeida

Affiliation

¹ Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900 Juiz de Fora, MG, Brazil.

PMID: 20888176
DOI: 10.1016/j.biopha.2010.06.002

Abstract

Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Alcohols / chemistry
Amino Alcohols / pharmacology*
Animals
Diamines / chemistry
Diamines / pharmacology*
Dose-Response Relationship, Drug
Gentian Violet / pharmacology
Molecular Structure
Solubility
Trypanocidal Agents / chemistry
Trypanocidal Agents / pharmacology*
Trypanosoma cruzi / drug effects*
Trypanosoma cruzi / growth & development

Substances

Amino Alcohols
Diamines
Trypanocidal Agents
Gentian Violet