DNA strand exchange catalyzed by molecular crowding in PEG solutions

Chem Commun (Camb). 2010 Nov 21;46(43):8231-3. doi: 10.1039/c0cc03117h. Epub 2010 Sep 29.

Abstract

DNA strand exchange is catalyzed by molecular crowding and hydrophobic interactions in concentrated aqueous solutions of polyethylene glycol, a discovery of relevance for understanding the function of recombination enzymes and with potential applications to DNA nanotechnology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Circular Dichroism
  • DNA / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Nucleic Acid Conformation
  • Phase Transition
  • Polyethylene Glycols / chemistry*
  • Solutions / chemistry
  • Transition Temperature

Substances

  • Solutions
  • Polyethylene Glycols
  • DNA