Abstract
A highly efficient, two-stage, continuous-flow synthesis of vitamin D(3) from provitamin D(3) was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholecalciferol / chemical synthesis*
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Cholecalciferol / chemistry
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Chromatography, High Pressure Liquid / methods*
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Dehydrocholesterols / chemistry
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Ultraviolet Rays
Substances
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Dehydrocholesterols
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Cholecalciferol
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7-dehydrocholesterol