This is a review of analytical methods, such as spectrophotometry, derivative spectrophotometry and various chromatographic (gas chromatography-GC, high-performance liquid chromatography-HPLC, thin-layer chromatography-TLC, high-performance thin-layer chromatography-HPTLC, liquid chromatography-tandem mass spectrometry-LC-MS, microchip electrophoresis-MCE, capillary electrophoresis-CE) and electroanalytical methods (differential pulse polarography-DPP, cathodic stripping voltammetry-CSV, anodic stripping voltammetry-ASV, differential pulse voltammetry-DPV, cyclic voltammetry-CV, stripping voltammetry-SV, square wave voltammetry-SWV, square wave polarography-SWP) that are used in the analysis of hypotensive complex agents. This review is based on representative publications that were published between 1995 and 2009.