The usefulness of toluidine red unheated serum test in the diagnosis of HIV-negative neurosyphilis

Sex Transm Dis. 2011 Mar;38(3):244-5. doi: 10.1097/OLQ.0b013e3181f42093.

Abstract

We retrospectively analyzed the Venereal Disease Research Laboratory test, Treponema pallidum particle agglutination test, and toluidine red unheated serum test (TRUST) in 41 cases of HIV-negative neurosyphilis and 34 non-neurologic syphilitic patient and found that serum-TRUST titers could be the indication of lumbar puncture in syphilitic patients and a reactive cerebrospinal fluid-TRUST is considered diagnostic to neurosyphilis.

MeSH terms

  • Agglutination Tests / methods
  • Antibodies, Bacterial / blood*
  • Antibodies, Bacterial / cerebrospinal fluid*
  • Azo Compounds*
  • Chi-Square Distribution
  • Humans
  • Leukocyte Count
  • Neurosyphilis / diagnosis*
  • Neurosyphilis / microbiology
  • Reagins / blood
  • Reagins / cerebrospinal fluid
  • Retrospective Studies
  • Sensitivity and Specificity
  • Syphilis Serodiagnosis / methods*
  • Treponema pallidum / isolation & purification*

Substances

  • Antibodies, Bacterial
  • Azo Compounds
  • Reagins
  • toluidine red