Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide

Jasminka Stefulj; Gordana Mokrovic; Dubravka Hranilovic; Tatjana Bordukalo-Niksic; Mirko Bakula; Milovan Kubat; Branimir Jernej

doi:10.1016/j.psychres.2010.08.034

Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide

Psychiatry Res. 2011 Apr 30;186(2-3):446-7. doi: 10.1016/j.psychres.2010.08.034.

Authors

Jasminka Stefulj¹, Gordana Mokrovic, Dubravka Hranilovic, Tatjana Bordukalo-Niksic, Mirko Bakula, Milovan Kubat, Branimir Jernej

Affiliation

¹ Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Zagreb, Croatia. stefulj@irb.hr

PMID: 20869124
DOI: 10.1016/j.psychres.2010.08.034

Abstract

The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chi-Square Distribution
Cohort Studies
Croatia / epidemiology
Gene Frequency
Genome-Wide Association Study
Genotype
Humans
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics*
Self-Injurious Behavior / genetics*
Suicide*
Tryptophan Hydroxylase / genetics*

Substances

TPH2 protein, human
Tryptophan Hydroxylase