cAMP diffusion in Dictyostelium discoideum: a Green's function method

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jul;82(1 Pt 1):011909. doi: 10.1103/PhysRevE.82.011909. Epub 2010 Jul 15.

Abstract

A Green's function method is developed to approach the spatiotemporal equations describing the cAMP production in Dictyostelium discoideum, markedly reducing numerical calculations times: cAMP concentrations and gradients are calculated just at the amoeba locations. A single set of parameters is capable of reproducing the different observed behaviors, from cAMP synchronization, spiral waves and reaction-diffusion patterns to streaming and mound formation. After aggregation, the emergence of a circular motion of amoebas, breaking the radial cAMP field symmetry, is observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Cyclic AMP / chemistry*
  • Dictyostelium / chemistry*
  • Models, Biological*
  • Models, Chemical*

Substances

  • Cyclic AMP