Osteoid osteoma is a small benign bone lesion. It generally affects children and young adults. Traditional treatment of osteoid osteoma includes excision either by wide resection, or by the removal of the nidus using curettes and burrs after opening the overlying cortex. Newly developed techniques involve percutaneous ablation of the tumor by computed tomography-guided core-drill excision and destruction of the nidus by thermocoagulation. Fluoroscopic guided percutaneous extirpation and drilling resection procedures have been performed at the Institute for Health Care of Children and Youth, Pediatric Surgery Clinic in Novi Sad, Serbia. Some modifications in the methods were made and implemented, which resulted in an excellent cost-benefit ratio, shorter period of hospitalization, and faster recovery. The aim of this paper is to present the experience gained in the treatment of osteoid osteomas in the last 5 years at the Pediatric Surgery Clinic in Novi Sad and to describe the modifications to the percutaneous biopsy technique of osteoid osteoma that have been implemented.