Abstract
Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Dimerization*
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Ligands
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Molecular Sequence Data
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Nucleic Acid Hybridization
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Peptide Nucleic Acids / chemistry*
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Peptide Nucleic Acids / metabolism
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Protein Binding
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Protein Multimerization*
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Protein Structure, Quaternary
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Receptors, TNF-Related Apoptosis-Inducing Ligand / chemistry*
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Receptors, TNF-Related Apoptosis-Inducing Ligand / metabolism*
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Surface Plasmon Resonance
Substances
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Ligands
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Peptide Nucleic Acids
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Receptors, TNF-Related Apoptosis-Inducing Ligand