Abstract
Both C19 and C34 spiroketal domains of okadaic acid were assembled using gold(I) chloride catalyzed spiroketalizations, and the two resulting fragments were coupled to give the C15-C38 fragment of okadaic acid, a known intermediate for the total synthesis of this important natural product.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Furans / chemistry*
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Gold / chemistry*
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Molecular Structure
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Okadaic Acid / chemical synthesis*
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Spiro Compounds / chemistry*
Substances
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Furans
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Spiro Compounds
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spiroketal
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Okadaic Acid
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Gold