Abstract
Here we describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depend upon the combination of thiols assembled onto the nanoparticles. The most active conjugate displayed 99.9% growth inhibition at 0.5 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Escherichia coli / drug effects*
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Escherichia coli / growth & development
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Escherichia coli Infections / drug therapy
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Gold / chemistry*
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Ligands
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Metal Nanoparticles / chemistry*
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Small Molecule Libraries / chemistry*
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Small Molecule Libraries / pharmacology*
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Sulfhydryl Compounds / chemistry
Substances
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Anti-Bacterial Agents
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Ligands
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Small Molecule Libraries
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Sulfhydryl Compounds
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Gold