IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship

Biosci Biotechnol Biochem. 2010;74(9):1878-83. doi: 10.1271/bbb.100275. Epub 2010 Sep 7.

Abstract

The IgE-suppressive activity of (-)-matairesinol is demonstrated, and the structure-activity relationship of (-)-matairesinol clarified. 3',4-Dihydroxy-3,4'-dimethoxylignano-9,9'-lactone showed higher IgE-suppressive activity than (-)-matairesinol without any cytotoxic activity. Some derivatives bearing a longer and more bulky alkoxy group at the 3 or 4 position showed IgE-accelerative activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Survival / drug effects
  • Furans / chemistry*
  • Furans / pharmacology*
  • Furans / toxicity
  • Humans
  • Immunoglobulin E / drug effects*
  • Lactones
  • Lignans / chemistry*
  • Lignans / pharmacology*
  • Lignans / toxicity
  • Structure-Activity Relationship

Substances

  • Furans
  • Lactones
  • Lignans
  • Immunoglobulin E
  • matairesinol