Baimantuoluosides D-G, four new withanolide glucosides from the flower of Datura metel L

Arch Pharm Res. 2010 Aug;33(8):1143-8. doi: 10.1007/s12272-010-0802-4. Epub 2010 Apr 26.

Abstract

In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1-4). The structures of the new compounds are (5alpha,6alpha,7beta,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (1), (5alpha,6beta,7alpha,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (2), (5alpha,6beta,7alpha,12beta,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (3), and (5alpha,6beta,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Datura metel / chemistry*
  • Flowers
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Withanolides / chemistry*
  • Withanolides / isolation & purification

Substances

  • Glucosides
  • Withanolides