Biocompatibility evaluation is a fundamental step in developing new biomaterials. Implants derived from bovine tibial compact bone were analyzed with in vitro tests using fibroblast and osteoblast-like cells. Initially, cell attachment and proliferation were quantified. Results indicated that the pins did not interfere with normal cell adhesion and proliferation; more-over, cell morphology was observed using scanning electron microscopy (SEM) and confocal fluorescence microscopy. In vivo experiments to evaluate material osteointegration are currently in progress. (Journal of Applied Biomaterials and Biomechanics 2005; 3: 35-41).