Ultrasound ionization of biomolecules

Rapid Commun Mass Spectrom. 2010 Sep 15;24(17):2569-74. doi: 10.1002/rcm.4677.

Abstract

To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensins / chemistry
  • Animals
  • Carbohydrates / chemistry*
  • Cattle
  • Cholic Acid / chemistry
  • Fatty Acids / chemistry*
  • Insulin / chemistry
  • Ions / chemistry*
  • Linear Models
  • Proteins / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Ultrasonics / methods*

Substances

  • Angiotensins
  • Carbohydrates
  • Fatty Acids
  • Insulin
  • Ions
  • Proteins
  • Cholic Acid