Low temperature fabrication of magnesium phosphate cement scaffolds by 3D powder printing

J Mater Sci Mater Med. 2010 Nov;21(11):2947-53. doi: 10.1007/s10856-010-4148-8. Epub 2010 Aug 26.

Abstract

Synthetic bone replacement materials are of great interest because they offer certain advantages compared with organic bone grafts. Biodegradability and preoperative manufacturing of patient specific implants are further desirable features in various clinical situations. Both can be realised by 3D powder printing. In this study, we introduce powder-printed magnesium ammonium phosphate (struvite) structures, accompanied by a neutral setting reaction by printing farringtonite (Mg(3)(PO(4))(2)) powder with ammonium phosphate solution as binder. Suitable powders were obtained after sintering at 1100°C for 5 h following 20-40 min dry grinding in a ball mill. Depending on the post-treatment of the samples, compressive strengths were found to be in the range 2-7 MPa. Cytocompatibility was demonstrated in vitro using the human osteoblastic cell line MG63.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Bone Cements / chemical synthesis*
  • Bone Cements / chemistry
  • Bone Cements / pharmacology
  • Cell Survival / drug effects
  • Cells, Cultured
  • Cold Temperature*
  • Compressive Strength
  • Electroplating / methods
  • Humans
  • Magnesium Compounds / chemical synthesis
  • Magnesium Compounds / chemistry*
  • Magnesium Compounds / pharmacology
  • Materials Testing / methods
  • Microscopy, Electron, Scanning
  • Particle Size
  • Phosphates / chemical synthesis
  • Phosphates / chemistry*
  • Phosphates / pharmacology
  • Powders / chemical synthesis
  • Powders / chemistry
  • Tissue Scaffolds / chemistry*

Substances

  • Biocompatible Materials
  • Bone Cements
  • Magnesium Compounds
  • Phosphates
  • Powders
  • magnesium phosphate