Organocatalytic asymmetric Michael addition of alpha-aryl cyclopentanones to nitroolefins for construction of adjacent quaternary and tertiary stereocenters

Xiu-Qin Dong; Huai-Long Teng; Min-Chao Tong; He Huang; Hai-Yan Tao; Chun-Jiang Wang

doi:10.1039/c0cc01987a

Organocatalytic asymmetric Michael addition of alpha-aryl cyclopentanones to nitroolefins for construction of adjacent quaternary and tertiary stereocenters

Chem Commun (Camb). 2010 Sep 28;46(36):6840-2. doi: 10.1039/c0cc01987a. Epub 2010 Aug 20.

Authors

Xiu-Qin Dong¹, Huai-Long Teng, Min-Chao Tong, He Huang, Hai-Yan Tao, Chun-Jiang Wang

Affiliation

¹ College of Chemistry and Molecular Sciences, Wuhan University, 430072, China.

PMID: 20730148
DOI: 10.1039/c0cc01987a

Abstract

The first asymmetric Michael addition of alpha-aryl cyclopentanones to nitroolefins for construction of adjacent quaternary and tertiary stereocenters has been achieved with excellent diastereo-/enantioselectivity.