Getting past the RNA world: the initial Darwinian ancestor

Cold Spring Harb Perspect Biol. 2011 Apr 1;3(4):a003590. doi: 10.1101/cshperspect.a003590.

Abstract

A little-noted result of the confirmation of multiple premises of the RNA-world hypothesis is that we now know something about the dawn organisms that followed the origin of life, perhaps over 4 billion years ago. We are therefore in an improved position to reason about the biota just before RNA times, during the era of the first replicators, the first Darwinian creatures on Earth. An RNA congener still prominent in modern biology is a plausible descendent of these first replicators.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Earth, Planet
  • Evolution, Molecular*
  • Gene Expression Regulation
  • Models, Genetic
  • Proteins / genetics
  • Proteins / metabolism
  • RNA / genetics
  • RNA / metabolism*

Substances

  • Proteins
  • RNA