Abstract
Original palladium complexes involving (-)-ephedrine, (-)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Alcohols / chemical synthesis*
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Amino Alcohols / chemistry
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology
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Palladium / chemistry*
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Stereoisomerism
Substances
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Amino Alcohols
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Antineoplastic Agents
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Organometallic Compounds
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Palladium