Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae)

Mar Drugs. 2010 Jun 29;8(7):2014-20. doi: 10.3390/md8072014.

Abstract

A new bioactive sterol glycoside, 3beta-O-(3',4'-di-O-acetyl-beta-D-arabinopyranosyl)-25xi-cholestane-3beta,5alpha,6beta,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

Keywords: Carijoa; carijoside; cytotoxicity; elastase; glycoside; superoxide anion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Humans
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Pancreatic Elastase / drug effects
  • Pancreatic Elastase / metabolism
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Spectrum Analysis
  • Sterols / isolation & purification
  • Sterols / pharmacology
  • Superoxides / metabolism

Substances

  • 3-O-(3',4'-di-O-acetylarabinopyranosyl)cholestane-3,5,6,26-tetrol-26-acetate
  • Antineoplastic Agents
  • Glycosides
  • Saponins
  • Sterols
  • Superoxides
  • Pancreatic Elastase