Abstract
A new bioactive sterol glycoside, 3beta-O-(3',4'-di-O-acetyl-beta-D-arabinopyranosyl)-25xi-cholestane-3beta,5alpha,6beta,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
Keywords:
Carijoa; carijoside; cytotoxicity; elastase; glycoside; superoxide anion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Humans
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Neutrophils / drug effects
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Neutrophils / metabolism
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Pancreatic Elastase / drug effects
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Pancreatic Elastase / metabolism
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Saponins / isolation & purification
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Saponins / pharmacology*
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Spectrum Analysis
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Sterols / isolation & purification
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Sterols / pharmacology
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Superoxides / metabolism
Substances
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3-O-(3',4'-di-O-acetylarabinopyranosyl)cholestane-3,5,6,26-tetrol-26-acetate
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Antineoplastic Agents
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Glycosides
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Saponins
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Sterols
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Superoxides
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Pancreatic Elastase