Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33

Hum Genet. 2010 Oct;128(4):461-3. doi: 10.1007/s00439-010-0871-y. Epub 2010 Aug 13.

Abstract

Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2-3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 3 / genetics*
  • Consanguinity
  • Family Health
  • Female
  • Genes, Recessive*
  • Genetic Linkage
  • Genome-Wide Association Study / methods*
  • Humans
  • Male
  • Pakistan
  • Pedigree
  • Stuttering / genetics*