The role of kisspeptin signaling in reproduction

Physiology (Bethesda). 2010 Aug;25(4):207-17. doi: 10.1152/physiol.00009.2010.

Abstract

Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.

Publication types

  • Review

MeSH terms

  • Animals
  • Gonadotropin-Releasing Hormone / genetics
  • Gonadotropin-Releasing Hormone / physiology
  • Humans
  • Kisspeptins
  • Neurons / physiology
  • Proteins / genetics
  • Rats
  • Reproduction / genetics*
  • Reproduction / physiology*
  • Signal Transduction / genetics*
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins / agonists
  • Tumor Suppressor Proteins / antagonists & inhibitors
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / physiology*

Substances

  • KISS1 protein, human
  • Kiss1 protein, rat
  • Kisspeptins
  • Proteins
  • Tumor Suppressor Proteins
  • Gonadotropin-Releasing Hormone