Universal recipients in the G2 phase of mitotic cell cycle (preactivated oocytes, zygotes, blastomeres) accept embryonic nuclei in all the stages of their cell cycle. To test if recipients in the G2 of meiotic cycle (immature oocytes) are universal recipients, mouse germinal vesicle (GV) oocytes were enucleated and reconstructed with blastomere nuclei in the G1, S, or G2 stages. Analysis of their maturation has shown that about 30% of the G1 nuclei and 60% of G2 nuclei allow for normal metaphase II (MII), both in the oocytes with and without the first polar body (1st PB). Among oocytes reconstructed with the S phase nuclei, only 8% or less have normal MII, although 75% of them extrude 1st PB. No phase of donor cell cycle prevented the abnormal acceleration of 1st PB extrusion, found in reconstructed GV oocytes. In conclusion, enucleated GV oocytes are not universal recipients of embryonic nuclei, because they do not accept the S donors. However, both the G1 and G2 donor nuclei can be reprogrammed in the GV oocyte cytoplasm.