Ultrasound-guided percutaneous injection of triamcinolone acetonide for treating capsular contracture in patients with augmented and reconstructed breast

Eur Radiol. 2011 Mar;21(3):575-81. doi: 10.1007/s00330-010-1921-5. Epub 2010 Aug 9.

Abstract

Objectives: To evaluate ultrasound (US)-guided treatment of capsular contracture (CC) in patients with reconstructed/augmented breast.

Methods: Twenty-five patients with grade IV CC were treated with peri-implant US-guided injection of triamcinolone acetonide. Before/after treatment, maximum capsular thickness (MCT) was measured by ultrasound and pain assessed with visual analogue score (pain-VAS). Patients with pain relief at 1 month were considered early responders (ERs). Another injection was performed in patients without pain relief at 1 month (late responders, LRs).

Results: One patient (treated with chemo-radiotherapy) experienced severe pain and local reaction after the second injection, requiring surgery. Twenty-four patients had baseline MCT of 1.8 ± 0.3 mm and pain-VAS of 4.9 ± 0.5, the baseline MCT of 19 ERs (1.7 ± 0.2 mm) being significantly lower than that of 5 LRs (2.1 ± 0.2 mm) (p = 0.030). ERs had significantly reduced MCT and pain-VAS at one (1.1 ± 0.3 mm; 1.5 ± 0.5) and 6 months (1.1 ± 0.2 mm; 0.9 ± 0.7, respectively) (p < 0.001). At 1 month, LRs had a significantly reduced MCT (1.6 ± 0.1 mm, p = 0.042) but non-significantly changed pain-VAS (4.7 ± 0.2); 5 months later, MCT reached 1.0 ± 0.1 mm, pain-VAS reached 0.8 ± 0.5 (p < 0.044). Significant correlation between the relative variation of MCT and pain-VAS (1 month/baseline) was found.

Conclusions: US-guided injection of triamcinolone acetonide is effective in treating grade IV CC.

MeSH terms

  • Anti-Inflammatory Agents / administration & dosage
  • Breast Diseases / diagnostic imaging*
  • Breast Diseases / drug therapy*
  • Breast Diseases / etiology
  • Breast Implants / adverse effects*
  • Contracture / diagnostic imaging*
  • Contracture / drug therapy*
  • Contracture / etiology
  • Female
  • Humans
  • Injections, Intralesional / methods
  • Treatment Outcome
  • Triamcinolone / administration & dosage*
  • Ultrasonography, Interventional / methods*

Substances

  • Anti-Inflammatory Agents
  • Triamcinolone