Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules

Subbiah Nagarajan; Pandian Arjun; Nanjian Raaman; Thangamuthu Mohan Das

doi:10.1016/j.carres.2010.07.016

Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules

Carbohydr Res. 2010 Sep 23;345(14):1988-97. doi: 10.1016/j.carres.2010.07.016. Epub 2010 Jul 11.

Authors

Subbiah Nagarajan¹, Pandian Arjun, Nanjian Raaman, Thangamuthu Mohan Das

Affiliation

¹ Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.

PMID: 20688320
DOI: 10.1016/j.carres.2010.07.016

Abstract

Regioselective facile one-pot synthesis of 16 different sugar-based quinoline, naphthyridine, and xanthone derivatives is reported. The compounds are characterized by NMR spectroscopy and elemental analysis. The beta-Anomeric form of the sugar moiety was identified from (1)H NMR studies. Antimicrobial studies of these sugar-heterocyclic derivatives, 3a, 3b, 3f, 5c, 7a, 7b, and 7c show excellent activity against different microbes.

MeSH terms

Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / pharmacology
Glycosides / chemistry
Lactones / chemistry
Microbial Sensitivity Tests
Naphthyridines / chemical synthesis*
Naphthyridines / pharmacology
Nuclear Magnetic Resonance, Biomolecular
Quinolines / chemical synthesis*
Xanthones / chemical synthesis*
Xanthones / pharmacology

Substances

Anti-Infective Agents
Glycosides
Lactones
Naphthyridines
Quinolines
Xanthones