Synthesis, crystal structure, antioxidant activity, and DNA-binding studies of a novel Ni(II) [2x2] grid complex with a rigid bistridentate Schiff base ligand

Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1077-80. doi: 10.1248/cpb.58.1077.

Abstract

With a bistridentate Schiff-base ligand, N',N'(3)-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H(2)L), a [2x2]G grid complex, [Ni(4)(HL)(4)](ClO(4))(4).4H(2)O.0.5 CH(3)OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound 1 strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(II) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Binding Sites
  • Cattle
  • Crystallography, X-Ray
  • DNA / chemistry*
  • DNA / drug effects
  • Free Radical Scavengers / chemical synthesis
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Hydroxyl Radical / chemistry
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • Nickel / chemistry*
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Schiff Bases / chemistry*
  • Superoxides / chemistry

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Ligands
  • Organometallic Compounds
  • Schiff Bases
  • Superoxides
  • Hydroxyl Radical
  • Nickel
  • DNA
  • calf thymus DNA