Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica

Giuseppina Chianese; Serge R Yerbanga; Leonardo Lucantoni; Annette Habluetzel; Nicoletta Basilico; Donatella Taramelli; Ernesto Fattorusso; Orazio Taglialatela-Scafati

doi:10.1021/np100325q

Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica

J Nat Prod. 2010 Aug 27;73(8):1448-52. doi: 10.1021/np100325q.

Authors

Giuseppina Chianese¹, Serge R Yerbanga, Leonardo Lucantoni, Annette Habluetzel, Nicoletta Basilico, Donatella Taramelli, Ernesto Fattorusso, Orazio Taglialatela-Scafati

Affiliation

¹ Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131, Napoli, Italy.

PMID: 20669933
DOI: 10.1021/np100325q

Abstract

Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / pharmacology*
Azadirachta / chemistry*
Burkina Faso
Fruit / chemistry
Limonins / chemistry
Limonins / pharmacology
Plants, Medicinal / chemistry*
Structure-Activity Relationship
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*

Substances

Antimalarials
Limonins
Triterpenes
azadirone
neemfruitin A
neemfruitin B
gedunin