Abstract
Eight novel tirucallane-type alkaloids (1-8) and 11 known compounds were isolated from a methanol extract of the bark of Dysoxylum laxiracemosum. The structures of 1-8 were elucidated using extensive NMR spectrometric and mass spectroscopic methods. Compounds 1 and 5, named laxiracemosins A and E, showed significant cytotoxicity against five human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Female
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HL-60 Cells
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Humans
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Meliaceae / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Triterpenes
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laxiracemosin A
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laxiracemosin E
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tirucallane