Limonoids from the leaves of Cipadessa baccifera

J Nat Prod. 2010 Aug 27;73(8):1327-31. doi: 10.1021/np900852d.

Abstract

Eight new limonoids with four different structural frameworks, including gedunin (1, 2), havanensin (3, 4), mexicanolide (5, 6), and methyl angolensate types (7, 8), together with six known limonoids, were isolated from the leaves of Cipadessa baccifera. Compounds 2 and 5 exhibited moderate cytotoxicity against the HL-60 cell line with an IC(50) value of 20 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Limonins / chemistry
  • Limonins / isolation & purification*
  • Limonins / pharmacology
  • Meliaceae / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Limonins