Long-term cereal-based nutritional supplementation improved the total spine bone mineral density amongst Sri Lankan preschool children: a randomized controlled study

J Pediatr Endocrinol Metab. 2010 Jun;23(6):555-63. doi: 10.1515/jpem.2010.094.

Abstract

Background: The Thriposha programme in Sri Lanka provides a combination of energy, protein and micronutrients as a 'ready-to-eat' cereal-based food.

Objective: To assess the effectiveness of calcium and vitamin D3 in the Thriposha on bone mineralization among preschool children aged 3-5 years.

Design: Subjects (n = 30) were fed with conventional Thriposha while the control group (n = 30) children were fed without mineral and vitamin premix (Corn-Soya-Blend - CSB) for a period of nine months. Dual-energy X-ray absorptiometry (DXA) of total spine was measured at the baseline and after the intervention.

Results: The mean baseline total spine BMD was 0.464 (0.050) g/cm2 in the interventional group and 0.453 (0.035) g/cm2 in the control group (p = 0.09). At the end of the study, the BMD levels were 0.487 (0.047) and 0.454 (0.031) g/cm2 (p < 0.001) respectively.

Conclusion: Daily supplementation of cereal based food supplement over a period of nine months improved the total spine BMD.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Blood Chemical Analysis
  • Bone Density / drug effects*
  • Bone Density / physiology
  • Calcium, Dietary / administration & dosage*
  • Child, Preschool
  • Cholecalciferol / administration & dosage*
  • Dietary Supplements
  • Edible Grain*
  • Female
  • Hematologic Tests
  • Humans
  • Male
  • Spine / diagnostic imaging
  • Spine / drug effects*
  • Spine / metabolism

Substances

  • Calcium, Dietary
  • Cholecalciferol