Abstract
Objective:
The purpose of this study was to evaluate the immunohistochemical Rb2/p130 expression in a series of benign, borderline, and malignant ovarian tumors.
Study design:
Seventy-six operative specimens were analyzed. Frequencies and percents were calculated for variables by each of the 5 disease stage groups in increasing severity and again for the disease stage groups collapsed into benign (serous cystadenoma or endosalpingosis), low-grade [serous borderline tumors (SBT) or low-grade serous carcinoma (LGSC)] and high-grade serous carcinoma.
Results:
There was no loss of expression in benign serous cystadenomas (0/18). Ten percent of SBT's (2/20), 47% of LGSC's (9/19), and 16% of HGSC's (3/16) had loss of expression. There was a significant difference in the expression during the progression from cystadenoma to SBT to LGSC.
Conclusions:
Loss of Rb2/p130 expression is a rare event in benign cystadenoma. The progression to LGSC is associated with a decrease in gene expression.
MeSH terms
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Acetylglucosamine* / analogs & derivatives
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Acetylglucosamine* / analysis
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Acetylglucosamine* / metabolism
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Adult
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Aged
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Aged, 80 and over
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Animals
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Biomarkers, Tumor* / analysis
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Biomarkers, Tumor* / genetics
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Biomarkers, Tumor* / metabolism
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Carcinoma / classification*
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Carcinoma / genetics*
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Carcinoma / metabolism
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Carcinoma / pathology
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Cell Line, Tumor
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Cystadenoma / genetics*
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Cystadenoma / metabolism
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Cystadenoma / pathology*
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Endothelium / physiopathology
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Female
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Gene Expression Profiling
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Gene Transfer Techniques
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Glioblastoma / genetics
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Glioblastoma / immunology*
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Glioblastoma / metabolism*
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Glioblastoma / pathology
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Glycosylation
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Humans
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Immunohistochemistry / methods
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Lectins* / chemistry
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Male
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Membrane Glycoproteins / chemistry*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / immunology
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Membrane Glycoproteins / metabolism*
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Mice
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Mice, Nude
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Middle Aged
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N-Acetylglucosaminyltransferases / metabolism*
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Neoplasm Staging
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Ovarian Neoplasms / genetics*
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology*
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Ovary / physiopathology
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Paraffin Embedding
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Phytohemagglutinins / chemistry*
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Predictive Value of Tests
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Retinoblastoma-Like Protein p130* / analysis
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Retinoblastoma-Like Protein p130* / genetics
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Retinoblastoma-Like Protein p130* / metabolism
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Transplantation, Heterologous
Substances
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Biomarkers, Tumor
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Lectins
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Membrane Glycoproteins
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Phytohemagglutinins
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Retinoblastoma-Like Protein p130
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erythroagglutinating phytohemagglutinin
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N-Acetylglucosaminyltransferases
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Acetylglucosamine