Abstract
The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. α-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism*
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Antimicrobial Cationic Peptides / metabolism*
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Antimicrobial Cationic Peptides / pharmacology*
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Bacterial Proteins / metabolism
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DNA-Directed DNA Polymerase / metabolism
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Enzyme Activation / drug effects
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Luciferases, Firefly / metabolism
Substances
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Antimicrobial Cationic Peptides
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Bacterial Proteins
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Adenosine Triphosphate
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Luciferases, Firefly
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DNA-Directed DNA Polymerase